Hypoprothrombinemia Caused by Vitamin K-Antagonist Anticoagulantsĭrug of choice for the treatment of moderate or severe hemorrhage caused by overdosage of vitamin K-antagonist anticoagulants (coumarin or indandione derivatives). More effective than and preferred to other vitamin K preparations in the presence of impending or actual hemorrhage. Prophylaxis and/or treatment of coagulation disorders due to faulty formation of factors II, VII, IX, and X caused by vitamin K deficiency or interference with vitamin K activity. (See Administration under Dosage and Administration.)Ī fat-soluble naphthoquinone derivative identical to naturally occurring vitamin K 1. Manufacturers recommend restriction of IV and IM administration to those situations where sub-Q administration is not feasible and the serious risk associated with IV or IM administration is considered justified. ![]() These severe reactions have included shock and cardiac and/or respiratory arrest and have occurred after initial and subsequent administrations. Such severe reactions have occurred after initial and subsequent administrations despite employing measures to prevent hypersensitivity reactions, including dilution of the injection and administration by slow infusion. Severe and fatal hypersensitivity reactions, including anaphylaxis, have occurred during and immediately after IV or IM administration of phytonadione injection. Hypersensitivity Reactions with IV or IM Administration
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